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Home β€Ί Medicine β€Ί Spexib 150mg Capsule
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Spexib 150mg Capsule

Prescription Required Cold Chain i
Salt Composition CERITINIB
Marketer NOVARTIS INDIA LTD
Prepaid Only. Non-Returnable.
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This medicine is prepaid
only and cannot be
returned once delivered.
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Introduction to Spexib 150mg Capsule

Spexib 150 mg Capsule contains the active ingredient ceritinib. It is an anti-cancer (antineoplastic) medication that belongs to a class of drugs known as tyrosine kinase inhibitors. This medicine is prescribed for the treatment of adults with a specific type of lung cancer called anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC).

Do not take Spexib 150 mg Capsule if you are allergic to ceritinib or any of the other ingredients in this medicine. Before starting treatment, inform your doctor if you have a history of kidney, lung, liver, or pancreatic problems, or if you have diabetes or issues with blood sugar control.

Tell your doctor if you have any heart conditions, including a prolonged QT interval (an abnormality in the heart’s electrical activity), or if you are taking steroid medications. During treatment, your doctor will perform regular blood tests to monitor your liver, blood counts, and pancreatic functionβ€”typically every two weeks for the first three months and monthly thereafter.

Avoid consuming grapefruit or grapefruit juice while taking this medication, as it may increase the levels of the drug in your bloodstream.

Inform your doctor immediately if you are pregnant, planning to become pregnant, or think you may be pregnant. Effective contraception should be used during treatment and for at least 90 days after completing therapy. Oral contraceptives may not be fully effective when taken with this medicine, so discuss suitable birth control options with your doctor. You should also consult your doctor regarding any concerns about fertility before starting treatment.

Uses of Spexib 150mg Capsule

Anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC)

Therapeutic Effects of Spexib 150mg Capsule

ALK gene is a fusion protein that signals the cells to grow and divide uncontrollably, leading to the development of cancer. Spexib 150mg works by binding to the ALK protein, preventing its activity and stopping the growth and spread of cancer cells.

Interaction of Spexib 150mg Capsule with other drugs

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications such as ritonavir, Antifungal, antibiotics, anti-epileptics, and other medications may interact with Spexib 150mg and reduce its effectiveness by causing undesirable side effects.

More Information about Spexib 150mg Capsule

Do not store above 30˚C Keep it in the original container Keep this medicine out of the sight and reach of children.

How to consume Spexib 150mg Capsule

Take the capsules at about the same time each day. The recommended dose is 450mg, taken once daily with food. Swallow the capsules whole and do not crush, chew, dissolve, or open the capsules. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.

Side Effects of Spexib 150mg Capsule

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
Increase urination
Irregular heartbeat
Cough with or without mucus
Fever Chest pain
Difficulty in breathing or swallowing
Swelling in the face, lips, tongue or throat
Severe itching in the skin with bumps or red rash
Right side abdomen pain
Bleeding and Bruises
Common
Decreased appetite
Anemia
The lower level of phosphate
Diarrhea
Nausea
Vomiting
Stomach ache
Constipation
Skin rash

Safety Advice for Spexib 150mg Capsule

Breast Feeding
Unsafe
It is unsafe to breastfeed while taking Spexib 150mg because it can cause toxicity to the baby. Consult your physician for more information.
Alcohol-Consult your doctor
Alcohol
Consult Your Doctor
It is unknown whether it is safe to consume alcohol with Spexib 150mg. Please consult your doctor for more information.
Liver-unsafe
Liver
Unsafe
Inform your physician about any underlying liver disorders before taking Spexib 150mg, as this medication should be used with caution in liver disease patients. Consult your physician before taking this medicine.
Lungs-Consult your doctor
Lungs
Consult Your Doctor
Inform your physician about any underlying lung disorders before taking Spexib 150mg, as this medication should be used with caution in such conditions. Consult your physician before taking this medicine. Notify your doctor if you experience any lung-related symptoms, such as difficulty breathing.
Driving-unsafe
Driving
Unsafe
It is unsafe to drive while taking Spexib 150mg because this medicine might cause vision problems and tiredness, so avoid driving and operating machinery during this treatment.
Pregnancy-unsafe
Pregnancy
Unsafe
This medicine is unsafe for use during pregnancy. Hence, check with your physician if you are pregnant or think you might be pregnant before taking this medicine. Use effective contraception methods.

Word of Advice for Spexib 150mg Capsule

Your doctor may perform an electrocardiogram to check your heart functioning level. It is important to take Spexib 150mg daily as long as your doctor prescribes it. Use highly effective contraception during and after the treatment for three months. Your doctor may conduct a blood test every two weeks of the first three months to monitor liver, blood, and pancreas function. If you vomit after taking the capsule, do not take another one. Notify your doctor if you experience any side effect symptoms, as your doctor may change the dosage of this medicine or give additional medicine to reduce the effect of the side effects.

FAQs about Spexib 150mg Capsule

Q1. Q1. Can Spexib 150mg cause liver damage?

Spexib 150mg may cause liver function abnormalities, indicating liver damage. It is important to have regular blood tests to monitor your liver function while taking this medicine. If you experience symptoms of liver damage, such as jaundice or abdominal pain, you should contact your doctor immediately.

Q2. Q2. Does Spexib 150mg cure cancer?

Spexib 150mg is not a cure for cancer, but it can help to slow down or stop the growth and spread of cancer cells, improving the overall survival and quality of life of patients with certain types of cancer.

Q3. Q3. Who should not take Spexib 150mg?

Spexib 150mg should not be taken by pregnant or breastfeeding women or by people with certain medical conditions such as severe liver or lung, heart disease, a history of pancreatitis, diabetes, or a prolonged QT interval.

Q4. Q4. Will there be a reduction of RBC (anemia) while taking Spexib 150mg?

Yes, one of the common side effects of this medicine is anemia. Spexib 150mg can cause anemia by suppressing the production of red blood cells.

Q5. Q5. Why are there low phosphate levels in the blood while taking Spexib 150mg?

The exact mechanism by which Spexib 150mg causes hypophosphatemia (low level of phosphate) is not fully understood, but it is thought to be related to the inhibition of certain enzymes involved in phosphate transport and metabolism in the body.

Fact Box of Spexib 150mg Capsule

Molecule Name CERITINIB
Marketer NOVARTIS INDIA LTD

References for Spexib 150mg Capsule

1.Bing Xia, Roy S. Herbst, Management of Advanced Non–Small Cell Lung Cancer: Noncurative Intent Treatment, Lung Cancer: A Practical Approach to Evidence-Based Clinical Evaluation and Management, 2018, 99-115.
2.Novartis Pharmaceuticals, Electronic Medicines Compendium(EMC), [Revised on Jan 2020] [Accessed on 26th April 2023]
3.Novartis Pharmaceuticals, Central Drugs Standard Control Organisation, [Revised on 22nd Jan 2019] [Accessed on 26th April 2023
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Spexib 150mg Capsule
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