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Home › Medicine › Rybrevant 350mg Injection
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Rybrevant 350mg Injection

Prescription Required Cold Chain i
Salt Composition AMIVANTAMAB
Marketer JOHNSON & JOHNSON PVT
Prepaid Only. Non-Returnable.
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This medicine is prepaid
only and cannot be
returned once delivered.
10% OFF
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Introduction to Rybrevant 350mg Injection

Rybrevant 350 mg Injection contains Amivantamab, an anticancer medicine classified as a bispecific antibody. It is used to treat non-small cell lung cancer (NSCLC) that has spread to other parts of the body, is not operable, or has progressed during or after prior anticancer treatments. This treatment is specifically for cancers with certain changes in the EGFR gene.

Do not use this injection if you are allergic to amivantamab or any of its ingredients. Before starting therapy, inform your doctor if you have a history of lung inflammation or any other lung-related conditions. Seek immediate medical attention if you experience sudden difficulty breathing, persistent cough, or fever, as these may be signs of lung inflammation.

Rybrevant 350 mg Injection is not recommended for children or adolescents under 18 years of age. Inform your healthcare provider if you have kidney, liver, or lung problems before beginning treatment.

Common side effects may include rash, nail inflammation, muscle or joint pain, shortness of breath, nausea, fatigue, swelling, mouth sores, cough, constipation, and vomiting. This medicine may harm an unborn baby, so women of childbearing potential should use effective contraception during treatment.

Uses of Rybrevant 350mg Injection

Non-small cell lung cancer (NSCLC)

Therapeutic Effects of Rybrevant 350mg Injection

Rybrevant 350mg injection is an epidermal growth factor receptor (EGFR), and mesenchymal-epithelial transition factor (MET) targeted bispecific antibody that has been designed to recognize and attach to specific targets in the body. It targets two proteins found in cancer cells. It works by attaching to these proteins and may help to slow or stop your lung cancer from growing. It may also reduce the size of the tumor.

Interaction of Rybrevant 350mg Injection with other drugs

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Rybrevant 350mg injection and reduce its effectiveness by causing undesirable side effects.

More Information about Rybrevant 350mg Injection

Store Rybrevant 350mg injection in the refrigerator (2°C to 8°C) Do not freeze keep the injection away from the reach of children and pets. If you have missed any dosing appointments, inform your doctor and schedule immediately.

How to consume Rybrevant 350mg Injection

It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. It is given as an intravenous infusion drip (into your vein) for several hours. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

Side Effects of Rybrevant 350mg Injection

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
Swelling in the face, hands, and feet
Inflammation in the nails
Constipation
Nausea, vomiting
Inflamed and sore mouth
Musculoskeletal pain
Cough
Shortness of breath
Tiredness
Serious
Severe rashes in the skin
Eye pain and infection
Inflammation of the lungs
Infusion reactions

Safety Advice for Rybrevant 350mg Injection

Breast Feeding
Unsafe
Breastfeeding is not recommended in patients taking Rybrevant 350mg injection because the medicine passes into the breast milk in small amounts and may harm your baby.
Alcohol-Consult your doctor
Alcohol
Consult Your Doctor
It is unknown whether consuming alcohol is safe during the treatment with Rybrevant 350mg injection. Inform your doctor if you are a chronic drinker.
Liver-Consult your doctor
Liver
Consult Your Doctor
It is unknown whether Rybrevant 350mg injection can be used in patients with liver disorders. Consult your doctor if you have any liver problems before starting the treatment.
Lungs-Consult your doctor
Lungs
Consult Your Doctor
It is unknown whether Rybrevant 350mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving-Consult your doctor
Driving
Consult Your Doctor
Rybrevant 350mg injection does not affect the ability to drive. If you feel tired or dizzy after taking this medicine, do not drive and consult your doctor for more advice.
Pregnancy-unsafe
Pregnancy
Unsafe
Rybrevant 350mg injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 3 months after your last dose is necessary.

Word of Advice for Rybrevant 350mg Injection

To reduce skin problems, limit sun exposure during and for 2 months after treatment, wear protective clothing, and apply sunscreen and moisturizers that are alcohol-free regularly on your skin and nails while taking this medicine. Contact your doctor or nurse immediately if you have eye pain or vision problems. Consult your doctor before using contact lenses when you are taking this medicine. Do not breastfeed during the treatment and for 3 months after the last dose. Your doctor may advise you to take certain tests to check for the effectiveness of the therapy.

FAQs about Rybrevant 350mg Injection

Q1. Q1. What are the infusion reactions that might happen during Rybrevant 350mg infusion?

Allergic reactions like itching. Swelling in your face or hands, tingling in mouth or throat, chest tightness, difficulty in breathing, fever, chills, cough, sore throat, body aches, unusual bleeding, bruising, or weakness should be informed to your doctor immediately.

Q2. Q2. How long should I have to take Rybrevant 350mg injection?

Rybrevant 350mg injection is given as a cycle therapy. Your doctor will decide the dose and duration of the therapy based on your disease severity and condition.

Q3. Q3. How long does Rybrevant 350mg infusion take?

Your first dose (the infusion on Day 1 and Day 2) can take about 4 to 6 hours. Infusions can get shorter starting on Week 2, and can take about 2 to 4 hours. Your doctor will decide the infusion rate based on your disease condition and other factors.

Q4. Q4. What are the eye problems that may occur while taking Rybrevant 350mg injection?

Eye pain, dry eyes, eye redness, blurred vision, changes in the vision, itchy eyes, excessive tearing, sensitivity to light are the eye problems that may occur with this treatment. Inform your physician if you face any of the symptoms.

Q5. Q5. Why should I avoid sun exposure during te treatment with Rybrevant 350mg injection?

Rybrevant 350mg injection can cause skin reactions. You should limit your time in the sun during your treatment with this medicine.

Q6. Q6. Can I take vitamin supplements with Rybrevant 350mg injection?

Certain medications may interact with the effectiveness of Rybrevant 350mg injection including prescription, over-the-counter medicines, vitamin or nutritional supplements and herbal products. Inform your physician about all your medication history.

Fact Box of Rybrevant 350mg Injection

Molecule Name AMIVANTAMAB
Marketer JOHNSON & JOHNSON PVT

References for Rybrevant 350mg Injection

1.Rybrevant (amivantamab) 50mg/mL concentrate for solution for infusion - Patient Information Leaflet (PIL) - (emc). www.medicines.org.uk. [revised on 2021] [cited 2023 Apr 6].
2.HIGHLIGHTS OF PRESCRIBING INFORMATION - amivantamab. [revised on 2021] [cited 2023 Apr 6]. Available from:
3.Park K, Haura EB, Leighl NB, Mitchell P, Shu CA, Girard N, et al. Amivantamab in EGFR Exon 20 Insertion–Mutated Non–Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results from the CHRYSALIS Phase I Study. Journal of Clinical
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Rybrevant 350mg Injection
₹76,752.00 MRP ₹85,075.89
Inclusive of all taxes 10% OFF
(You Save ₹8,323.89)
7 ML Injection in Vial

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