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Home › Medicine › Jemperli Injection
Substitutes

Jemperli Injection

Prescription Required Cold Chain i
Salt Composition DOSTARLIMAB
Marketer GLAXO SMITHKLINE PHARMACEUTICALS LTD
Prepaid Only. Non-Returnable.
?
This medicine is prepaid
only and cannot be
returned once delivered.
15% OFF
We are Rated 4.8 On Google

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Introduction to Jemperli Injection

Jemperli Injection is a prescription medication used to treat certain advanced or recurrent cancers. It belongs to a class of immunotherapy drugs known as immune checkpoint inhibitors, which work by targeting the programmed death receptor-1 (PD-1) pathway. By blocking PD-1, Jemperli helps reactivate the immune system, allowing it to recognize and destroy cancer cells more effectively.

This medicine is administered as an intravenous (IV) infusion, usually once every 3 to 6 weeks, and must be given under close medical supervision. Jemperli has demonstrated significant benefit in patients with mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) tumors, which are characterized by defects in DNA repair mechanisms.

During treatment, regular monitoring is essential, including checks of liver function, thyroid levels, and other immune-related effects. As an immunotherapy, Jemperli may cause the immune system to mistakenly attack healthy tissues, leading to immune-related adverse reactions.

Jemperli Injection is not recommended during pregnancy or breastfeeding. Patients with autoimmune diseases or a history of organ transplantation should inform their healthcare provider before starting treatment.

The price of Jemperli Injection may vary depending on the retailer and location

Uses of Jemperli Injection

Treatment of adult patients with recurrent or advanced dMMR/MSI-H endometrial cancer that has progressed on or after prior therapy and who are not candidates for curative surgery or radiation.

Treatment of adult patients with dMMR/MSI-H recurrent or advanced solid tumours (including colorectal cancer) that have progressed on or after prior treatment and have no satisfactory alternative options.

Investigated in clinical trials for ovarian cancer, endometrial cancer (first-line), and other advanced solid tumours.

Therapeutic Effects of Jemperli Injection

Enhances Immune System Activity: Blocks the PD-1 pathway, allowing immune cells (T-cells) to recognize and attack cancer cells more effectively. Effective in dMMR/MSI-H Tumors: Shows strong activity in cancers with mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) status, which are more responsive to immune checkpoint inhibitors. Controls Tumor Growth: Helps slow or stop the growth of advanced or recurrent cancers by promoting immune-mediated tumor destruction. Reduces Cancer Recurrence: Lowers the risk of disease progression or recurrence in eligible patients by sustaining immune surveillance against cancer cells. Targeted Immunotherapy Approach: Unlike chemotherapy, Jemperli does not directly kill cancer cells but stimulates the immune system, resulting in a more selective effect on tumor tissue. Improves Treatment Outcomes: Offers a valuable option for patients who have limited response to conventional cancer treatments. Jemperli Injection should be administered under specialist supervision with regular monitoring for immune-related side effects to ensure safe and effective treatment. If you want, I can also provide a simple patient-friendly explanation, mechanism of action, or a comparison with other PD-1 inhibitors.

Interaction of Jemperli Injection with other drugs

Tell your doctor if you are taking: Immunosuppressants (such as corticosteroids, cyclosporine, tacrolimus). Cancer therapies (chemotherapy, targeted therapy). Over-the-counter medicines, herbal products, or vitamins. Immunosuppressants may reduce the effectiveness of Jemperli Injection . Always provide your healthcare provider with a full list of medicines before treatment.

More Information about Jemperli Injection

Medical Supervision Required: Jemperli Injection must be given by a healthcare professional as an intravenous infusion. Do not miss scheduled appointments. Report Symptoms Early: Inform your doctor immediately if you notice signs of immune-related reactions such as persistent diarrhea, skin rash, shortness of breath, cough, fatigue, headache, or hormonal changes (unusual weight change, dizziness, or mood changes). Regular Monitoring Is Essential: Routine blood tests, including liver and thyroid function tests, are necessary to detect side effects early. Inform About Medical History: Tell your doctor if you have autoimmune diseases, a history of organ transplant, lung disorders, or previous immune-related reactions. Pregnancy & Breastfeeding Warning: Jemperli is not recommended during pregnancy or breastfeeding. Use effective contraception during treatment and as advised after the last dose. Avoid Self-Medication: Do not take steroids or immune-suppressing medicines unless prescribed by your doctor during treatment. Follow Treatment Schedule: Stick to the prescribed dosing schedule to achieve the best therapeutic outcome. Seek Urgent Care When Needed: Get immediate medical help if you experience chest pain, severe breathing difficulty, confusion, or severe allergic reactions.

How to consume Jemperli Injection

Administered as an intravenous (IV) infusion over 30 minutes by a healthcare provider. Dosing schedule: usually every 3 or 6 weeks, depending on treatment phase and protocol. Your doctor will determine the dose based on body weight, cancer type, and treatment plan.

Side Effects of Jemperli Injection

Serious (immune-related):
Pneumonitis (lung inflammation: cough, chest pain, shortness of breath)
Hepatitis (jaundice, dark urine, abdominal pain)
Colitis (diarrhoea, bloody stools, abdominal pain)
Endocrinopathies (thyroid, pituitary, adrenal problems causing fatigue, weight change, mood changes)
Severe skin reactions (rash, blistering, peeling)
Infusion reactions (fever, chills, dizziness, shortness of breath)
Common:
Fatigue
Nausea
Diarrhoea or constipation
Loss of appetite
Anemia
Cough
Rash or itching
Muscle/joint pain

Safety Advice for Jemperli Injection

Pregnancy
Unsafe
It is recommended to avoid Jemperli Injection during pregnancy, as it may harm the developing fetus. If you are pregnant, planning to become pregnant, or suspect pregnancy, consult your doctor before starting treatment. The doctor will assess the potential risks and benefits.
Breast Feeding-Consult Your Doctor
Breast Feeding
Consult Your Doctor
It is unknown whether Jemperli Injection passes into breast milk. Consult your doctor before taking this medicine while breastfeeding. The doctor may prescribe it only if the expected benefits outweigh the potential risks.
Lungs-Consult Your Doctor
Lungs
Consult Your Doctor
Immune checkpoint inhibitors like Jemperli Injection may cause inflammation in the lungs (pneumonitis). Consult your doctor if you have a history of lung disease or experience breathing difficulties before starting this treatment.
Liver-Consult Your Doctor
Liver
Consult Your Doctor
Jemperli Injection may cause immune-mediated hepatitis or elevate liver enzymes. Inform your healthcare provider if you have liver disease or abnormal liver function before starting treatment.
Alcohol-Consult Your Doctor
Alcohol
Consult Your Doctor
There is limited information on alcohol use with Jemperli Injection , but combining alcohol may worsen fatigue or affect liver function. Please consult your doctor before consuming alcohol during treatment.
Driving-Consult Your Doctor
Driving
Consult Your Doctor
Jemperli Injection may cause fatigue or dizziness in some patients. It is advised to avoid driving or operating heavy machinery until you understand how the medicine affects you.

Word of Advice for Jemperli Injection

Medical Supervision Required: Jemperli Injection must be given by a healthcare professional as an intravenous infusion. Do not miss scheduled appointments. Report Symptoms Early: Inform your doctor immediately if you notice signs of immune-related reactions such as persistent diarrhea, skin rash, shortness of breath, cough, fatigue, headache, or hormonal changes (unusual weight change, dizziness, or mood changes). Regular Monitoring Is Essential: Routine blood tests, including liver and thyroid function tests, are necessary to detect side effects early. Inform About Medical History: Tell your doctor if you have autoimmune diseases, a history of organ transplant, lung disorders, or previous immune-related reactions. Pregnancy & Breastfeeding Warning: Jemperli is not recommended during pregnancy or breastfeeding. Use effective contraception during treatment and as advised after the last dose. Avoid Self-Medication: Do not take steroids or immune-suppressing medicines unless prescribed by your doctor during treatment. Follow Treatment Schedule: Stick to the prescribed dosing schedule to achieve the best therapeutic outcome. Seek Urgent Care When Needed: Get immediate medical help if you experience chest pain, severe breathing difficulty, confusion, or severe allergic reactions.

FAQs about Jemperli Injection

Q1. Q1. What cancers is Jemperli Injection used for?

It is approved for dMMR/MSI-H endometrial cancer and solid tumours such as colorectal cancer after prior therapy.

Q2. Q2. What is the method of administering Jemperli Injection?

As an IV infusion every 3–6 weeks, depending on the treatment cycle.

Q3. Q3. Can I take Jemperli Injection with chemotherapy?

It may be used alone or in combination with chemotherapy in clinical trials. Your doctor will decide the best approach.

Q4. Q4. Does Jemperli Injection cause hair loss?

Unlike chemotherapy, it usually does not cause major hair loss, though some patients may experience mild thinning.

Q5. Q5. What is the recommended duration of Jemperli Injection therapy?

Treatment duration depends on your response and tolerance. Some patients continue for years if disease control is achieved.

Fact Box of Jemperli Injection

Molecule Name DOSTARLIMAB
Marketer GLAXO SMITHKLINE PHARMACEUTICALS LTD

References for Jemperli Injection

1.David O’Malley et al., “Checkpoint inhibition in mismatch repair-deficient tumors: Jemperli Injection outcomes,” The Lancet Oncology, [2022
2.U.S. FDA, “FDA grants accelerated approval to Jemperli Injection -gxly for dMMR endometrial cancer,” [April 2021]
3.EMA, “Jemperli (Jemperli Injection ): EPAR – Product Information,” [Accessed Sept 2025]
4.Luis A. Diaz Jr. et al., “Mismatch Repair Deficiency and Response to PD-1 Blockade in Colorectal Cancer,” The New England Journal of Medicine, [2022]
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Jemperli Injection
₹332,055.00 MRP ₹390,691.88
Inclusive of all taxes 15% OFF
(You Save ₹58,636.88)
10 ML Injection in Vial

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