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Home › Medicine › Enhertu 100mg Injection
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Enhertu 100mg Injection

Prescription Required Cold Chain i
Salt Composition TRASTUZUMAB DERUXTECAN
Marketer ASTRAZENECA
Prepaid Only. Non-Returnable.
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This medicine is prepaid
only and cannot be
returned once delivered.
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Introduction to Enhertu 100mg Injection

Enhertu 100mg Injection contains the active ingredient Trastuzumab deruxtecan, a targeted therapy used to treat specific types of breast and stomach cancers. It is prescribed for adult patients with HER2-positive breast cancer or HER2-positive gastric (stomach) cancer. This medication is not recommended for individuals under 18 years of age.

The standard dosing schedule for Enhertu is an infusion every three weeks, which is administered under the supervision of a healthcare professional in a clinical setting.

How Enhertu works:
Enhertu targets HER2-positive cancer cells, binding to them and delivering a cytotoxic (cell-killing) agent directly into the tumor cells. This approach helps destroy cancer cells while reducing damage to healthy tissues.

Comparisons:
Doctors sometimes compare Enhertu with Kadcyla, as both are HER2-targeted therapies for breast cancer. They differ in formulation, mechanism of action, and clinical outcomes, helping physicians choose the most suitable option for each patient.

Side effects:
As with all medications, Enhertu may cause side effects. Common reactions during infusion include nausea, vomiting, fatigue, decreased appetite, and infusion-related reactions. More serious side effects can involve lung or heart problems, so patients require regular monitoring.

Uses:

Treatment of HER2-positive metastatic breast cancer in patients who have previously received other anti-HER2 therapies.

Treatment of HER2-positive advanced gastric cancer in patients who have previously received a trastuzumab-based regimen.

Cost and availability:
The price of Enhertu 100mg Injection in India can vary depending on location and supplier. Monthly treatment costs may be high, so patients should discuss potential financial assistance programs with their doctor or pharmacist. Enhertu 100mg Injection can also be purchased online through licensed suppliers.

Uses of Enhertu 100mg Injection

Enhertu 100 mg injection uses are

Treats HER2-positive breast cancer that is metastatic or unresectable for patients who have had prior anti-HER2 treatments.

Effective for HER2-low metastatic breast cancer after prior chemotherapy.

Treats HER2-mutated non-small cell lung cancer (NSCLC) that is metastatic or unresectable following prior treatment.

Used for HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma after prior trastuzumab-based therapy.

For HER2-positive (IHC 3+) metastatic solid tumours when no other satisfactory treatments are available.

Therapeutic Effects of Enhertu 100mg Injection

Targeted cancer cell destruction: Enhertu binds specifically to HER2-positive cancer cells and delivers a cytotoxic (cell-killing) agent directly into them. This helps destroy tumor cells while minimizing harm to surrounding healthy tissue. Treatment of HER2-positive breast cancer: It is effective in metastatic or advanced HER2-positive breast cancer, particularly in patients who have already received other anti-HER2 therapies. Enhertu can help slow disease progression and reduce tumor size. Treatment of HER2-positive gastric (stomach) cancer: Enhertu is used in advanced or metastatic gastric cancer with HER2 overexpression in patients previously treated with trastuzumab-based regimens. It can improve survival and manage disease progression. Improved patient outcomes in resistant cancers: By delivering chemotherapy directly to HER2-positive cells, Enhertu is designed to overcome resistance to prior HER2-targeted therapies, offering a therapeutic option when other treatments have failed. Potential symptom relief: By reducing tumor burden, Enhertu may help alleviate cancer-related symptoms such as pain, fatigue, and loss of appetite in some patients.

Interaction of Enhertu 100mg Injection with other drugs

Inform your physician about all the prescribed medicine, over-the-counter medications, nutritional or vitamin supplements, and herbal supplements you have taken before. Certain medications may interact with Enhertu 100mg Injection and can cause undesirable side effects.

More Information about Enhertu 100mg Injection

Regularly monitor lung and liver functions with your doctor while taking Enhertu 100mg Injection due to possible side effects. Both women and men should use effective contraception during treatment. Women should continue birth control for at least 7 months after the final dose. Men should continue birth control for 4 months after completing treatment to avoid risks to partners who may become pregnant. Consult your doctor about the most suitable contraceptive methods and inform them before stopping contraception. Male patients should note that Enhertu 100mg Injection may affect fertility. Men are advised not to father a child for 4 months after treatment. Discuss sperm preservation options with your doctor before starting the medication.

How to consume Enhertu 100mg Injection

Enhertu 100mg Injection is administered through an intravenous (IV) infusion by a healthcare provider every three weeks. Before each treatment, you may receive medication to prevent nausea and vomiting. If you have an infusion-related reaction, the infusion may be slowed, paused, or permanently stopped for severe reactions. If you miss a dose, it's important to contact your healthcare provider immediately to reschedule. The number of treatments will depend on your healthcare provider's assessment. Your healthcare Provider will decide the Enhertu 100mg dosage and administration.

Side Effects of Enhertu 100mg Injection

Enhertu 100mg Injection Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious:
Severe allergic reactions (rashes, itching, difficulty in breathing, fever)
Common:
Nausea (feeling sick), vomiting
Tiredness
Decreased appetite
Blood tests showing decreased red or white blood cells or platelets
Hair loss
Diarrhoea
Constipation
Blood tests showing increased levels of the liver enzymes such as transaminases
Pain in muscles and bones
Weight loss
Fever
Abdominal (belly) pain
Infections of the nose and throat, including flu-like symptoms
Headache
Blisters in or around your mouth
Cough
Blood tests showing low blood potassium levels
Indigestion
Breathing difficulties
Swelling of ankles and feet
Nosebleed
Altered/bad taste in the mouth
Infection of the lungs

Safety Advice for Enhertu 100mg Injection

Breast Feeding
Unsafe
Enhertu 100mg Injection in nursing mothers has not been studied, and whether it is excreted in breast milk is unknown. Hence, it is not recommended to take this medication in breastfeeding mothers.
Alcohol-Consult Your Doctor
Alcohol
Consult Your Doctor
Enhertu 100mg Injection is not known to interact with alcohol. However, both Enhertu 100 mg Injection and alcohol can have similar side effects, such as headaches and nausea. Be vigilant about these side effects and contact your doctor for more advice.
Liver-Consult Your Doctor
Liver
Consult Your Doctor
Before beginning treatment with Enhertu 100mg Injection, it is important to let your doctor know if you suffer from liver impairment, as this may necessitate an adjustment in dosage depending on the severity of your liver condition.
Lungs-Unsafe
Lungs
Unsafe
If you have a history of lung disease, you may be at a higher risk of developing interstitial lung disease when using Enhertu 100mg Injection. Therefore, informing your doctor about any lung issues you have before beginning treatment with this medication is important.
Driving-Consult Your Doctor
Driving
Consult Your Doctor
Enhertu 100mg Injection does not impair your ability to drive or operate machinery. However, be cautious if you feel dizzy, tired, or have a headache. Contact your doctor for more advice.
Pregnancy-Unsafe
Pregnancy
Unsafe
Enhertu 100mg Injection, when taken during pregnancy, can cause neonatal complications. Hence, it is not recommended to take this medication if you are pregnant, planning for pregnancy or think you may become pregnant.

Word of Advice for Enhertu 100mg Injection

Regularly monitor lung and liver functions with your doctor while taking Enhertu 100mg Injection due to possible side effects. Both women and men should use effective contraception during treatment. Women should continue birth control for at least 7 months after the final dose. Men should continue birth control for 4 months after completing treatment to avoid risks to partners who may become pregnant. Consult your doctor about the most suitable contraceptive methods and inform them before stopping contraception. Male patients should note that Enhertu 100mg Injection may affect fertility. Men are advised not to father a child for 4 months after treatment. Discuss sperm preservation options with your doctor before starting the medication.

FAQs about Enhertu 100mg Injection

Q1. Q1. What is Enhertu used for?

Enhertu treats HER2-positive metastatic or unresectable breast cancer after prior anti-HER2 treatments. It is effective for HER2-low metastatic breast cancer, HER2-mutated metastatic non-small cell lung cancer (NSCLC), and HER2-positive gastric or gastroesophageal junction adenocarcinoma. It is also used for HER2-positive metastatic solid tumours when other treatments are unavailable.

Q2. Q2. Will Enhertu 100mg Injection affect my fertility?

Enhertu 100mg Injection may have an impact on fertility. If you are planning to have children in the future, it's crucial to discuss this with your healthcare provider before starting treatment. They may suggest fertility preservation options and provide guidance tailored to your personal and family plans.

Q3. Q3. Are there any foods to avoid while undergoing treatment with Enhertu 100mg Injection?

While on Enhertu 100mg Injection, managing nausea and vomiting is important, and your oncology care team can provide medications to help with these symptoms. Additionally, making changes to your diet can be beneficial. It's advisable to avoid foods that could aggravate these symptoms, such as heavy, greasy, or fatty foods and spicy or acidic items like lemons, tomatoes, and oranges

Q4. Q4. What is the usual treatment duration for Enhertu 100mg Injection in HER2-positive early breast cancer?

Based on the findings from four major studies, the standard treatment for patients with HER2-positive early breast cancer involves taking adjuvant Enhertu 100mg Injection for one year alongside chemotherapy. This approach has become the established method of care following these significant trials.

Q5. Q5. What is the success rate of Enhertu 100mg Injection in treating breast cancer?

The success of Enhertu 100mg Injection in treating breast cancer is significant. Clinical studies have shown that the five-year invasive breast cancer-free survival rate is 97.4% among patients treated with trastuzumab.

Q6. Q6. Can I continue my regular activities while undergoing treatment with Enhertu 100mg Injection?

Most patients can maintain their normal activities while on Enhertu 100mg Injection. However, you should monitor how you feel closely. Side effects like fatigue, nausea, or other symptoms might necessitate adjustments to your daily routine. Always consult your healthcare provider for personalized advice based on your situation.

Q7. Q7. What is the Enhertu price for 100mg injection?

The Enhertu 100 mg price typically ranges between ₹156,000 to ₹173,212, but it may vary depending on the location, healthcare provider, and specific patient needs.

Q8. Q8. What is the Enhertu annual price?

The Enhertu price per month typically ranges between ₹156,000 to ₹173,212. Based on this, the Enhertu annual cost will be between ₹1,872,000 to ₹2,078,544. The exact price may vary depending on the patient's treatment plan and location.

Fact Box of Enhertu 100mg Injection

Molecule Name TRASTUZUMAB DERUXTECAN
Marketer ASTRAZENECA

References for Enhertu 100mg Injection

1.Daiichi Sankyo UK Ltd, Electronic Medical Compendium (EMC),[Revised on July 2023][Accessed on Jan 2024]
2.Daiichi Sankyo, Inc, Food and Drug Safety Administration (FDA), [Revised on Jan 2021] [Accessed on Jan 2024]
3.KD Tripathi, Essentials of Medical Pharmacology, Chemotherapy For Neoplastic Diseases, 7th edition, 2013, 930.
4.Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Pharmacotherapy for Neoplastic Diseases, 12th edition, 2011, 1206.
In Stock
Enhertu 100mg Injection
₹137,499.00 MRP ₹167,069.17
Inclusive of all taxes 18% OFF
(You Save ₹29,570.17)
5 ML Injection in Vial

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