Celestras 500IU Injection

Prescription Required Cold Chain i

Salt Composition HUMAN C1-ESTERASE

Marketer Shire Biologics / Takeda Pharmaceuticals

Prepaid Only. Non-Returnable.

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Introduction to Celestras 500IU Injection

Celestras 500IU Injection contains Human C1-Esterase Inhibitor, a blood-derived protein used to manage hereditary angioedema (HAE). It replaces the deficient endogenous C1-inhibitor, preventing uncontrolled complement activation and swelling attacks. Requires cold storage and hospital administration. Available at ₹25615 (MRP ₹32018.44).

Uses of Celestras 500IU Injection

Hereditary angioedema (HAE) acute attacks, HAE prophylaxis, C1-INH deficiency management, Facial and laryngeal angioedema, Abdominal HAE attacks

Therapeutic Effects of Celestras 500IU Injection

Human C1-esterase inhibitor replaces deficient endogenous C1-INH protein, restoring normal complement and contact system regulation and preventing angioedema attacks.

Interaction of Celestras 500IU Injection with other drugs

No significant drug interactions established. Avoid concurrent use with tPA (thrombolytic agents) due to potential thrombotic risk.

More Information about Celestras 500IU Injection

For complete prescribing information, refer to the product insert.

How to consume Celestras 500IU Injection

Administered intravenously by a trained healthcare professional. Dose is based on body weight. Reconstitute and administer slowly.

Side Effects of Celestras 500IU Injection

Headache

Nausea and vomiting

Rash or skin reactions

Injection site pain

Thrombotic events (rare)

Fever

Safety Advice for Celestras 500IU Injection

Must be administered in clinical setting only

Cold storage required (2-8°C)

Monitor for thrombotic events

Have epinephrine available during infusion

Prescription mandatory — specialist use only

Word of Advice for Celestras 500IU Injection

Always carry your HAE emergency kit and medical alert card. Seek immediate care at first sign of laryngeal or abdominal attack.

FAQs about Celestras 500IU Injection

Q1. What is Celestras 500IU Injection used for?

It is used to treat and prevent hereditary angioedema (HAE) attacks.

Q2. Is a prescription required for this medicine?

Yes, strict prescription and specialist administration required.

Q3. How should this medicine be stored?

Store as per label instructions — most forms below 25-30°C, injectables and biologics at 2-8°C away from light.

Fact Box of Celestras 500IU Injection

Molecule Name	HUMAN C1-ESTERASE
Marketer	Shire Biologics / Takeda Pharmaceuticals

References for Celestras 500IU Injection

International WAO/EAACI HAE Guidelines 2021; BNF 2024; Prescribers' Digital Reference

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